By: Herne Webber

I have a solution to the problems listed about squalamine not have broad enough cellular coverage (types), and inability to cross the blood-brain barrier. Give the subject a precursor, or even two precursors and a binding enzyme together, which *inside every cell* would make squalamine. This is similar to what is done with acyclovir, which is only active in virally infected cells that make a particular kinase. All cells absorb this potentially lethal faux Guanosine, but only the ones with that viral kinase get the precursor turned into the lethal pro-DNA imposter. This mechanism should work, and can be keyed to some ensyme present more in cells that become infected with certain specific viruses, such that different cell lines would be protected from different, specific viruses.